This website is an information resource about Penthrox® intended for healthcare professionals only.
Patients who have been given Penthrox® can find the Patient Information Leaflet (PIL) here.
Report adverse events
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. By reporting side effects, you can help provide more information on the safety of medicine.
Mundipharma routinely monitors the safety of all its medicines, including reviewing safety data from clinical studies and collecting reports of adverse events. If you are a patient or are aware of a patient who has experienced an adverse event, overdose or unexpected benefits with one of our products, please also contact Mundipharma by calling +44 (0) 1223 424 211 or by emailing firstname.lastname@example.org. Mundipharma will only use your details to contact you about your adverse event report.
Penthrox® is a compact, lightweight, hand-held inhaler containing an analgesic dose of methoxyflurane. It is self-administered under supervision of a person trained in its administration and licensed for emergency relief of moderate-to-severe pain in conscious adult patients with trauma and associated pain.1
Please always refer to your local Summary of Product Characteristics.
Penthrox® has been used for over 40 years in Australia and New Zealand, with a total of over 6 million administrations.2,3,53
over 40 yrs
How could Penthrox® help you?
Non-opioid analgesic can be administered under the supervision of healthcare professionals such as nurses and paramedics.1,2
Penthrox® is easy to administer and can help overcome delays with analgesia administration vs. IV opioids.1,4
Because Penthrox® is easily portable and self-administered, multiple patients can be treated simultaneously.1,5
Rapid analgesic administration may improve patient flow.6
Penthrox® is not an opioid, it can be nurse or emergency crew initiated. The three easy steps to remember are: Pour, Breathe, Regulate, as shown in the guide.
Having ensured the activated carbon (AC) chamber is inserted into the dilutor hole on the top of the inhaler; rotate and tilt the inhaler then pour the entire contents of one 3mL bottle of Penthrox® into the base.
Ask patients to inhale through the mouthpiece, taking gentle breaths at first, then normal breaths, exhaling into the inhaler. For stronger analgesia, the patient can cover the dilutor hole on the AC chamber with a finger.
Instruct patients to inhale intermittently. Continuous inhalation shortens usage time. Use the minimum dose (3mL) to achieve analgesia. When finished, reseal the bottle and dispose of it with the inhaler, responsibly, in a sealed plastic bag.
A young male (early 30s) has been involved in a high-speed collision with another vehicle. He is conscious, has suspected multiple leg fractures, and requires stabilisation and moving to the ED.
On questioning, the patient reports severe pain (VAS=8), he is not receiving concomitant potentially nephrotoxic medication.
His vital signs (blood pressure, respiratory rate) are within normal boundaries.
Compact, lightweight, non-opioid Penthrox® can give this patient simple, fast, effective pain relief,1,2 even while he is trapped, allowing paramedics to focus on stabilising him for transporting him to the emergency department.
Penthrox® is self-administered (under supervision), meaning that multiple patients could be given pain relief simultaneously, at a scene where more vehicles are involved.5
Male (late 30s), mountain biking in rough terrain has fallen from a height of ~3m. He has a suspected leg injury and has significant pain in his left lower leg.
Pain is rated as severe VAS>8. He requires rapid evacuation by Air Ambulance.
The patient is conscious, haemodynamically stable and has good vital signs.
Easy to use, non-opioid Penthrox® offers fast and effective pain relief,1,2 potentially aiding a quicker transfer to hospital.
A young male football player (28 years), has suffered an awkward fall and has clearly dislocated his kneecap. He is conscious and reports moderate to severe pain (VAS>7). He has not suffered head trauma during his fall, is not on any medication and can understand how to use Penthrox®.
Penthrox® offers simple, fast, effective, pain relief that is inhaled, with no need for needles or injections.1,2 Because it is self-administered, the patient can control his own pain through his journey to the emergency department.
An elderly female in her 70s has fallen down the stairs and has a suspected fracture of the femur. The stairs are in a narrow hallway, access is very restricted. The patient needs to be moved to the ambulance for transport.
She reports severe pain VAS 7-9, and has good vital signs (blood pressure, respiratory rate).
Compact, portable and lightweight Penthrox® is simple to use, even when access is restricted; it is non-opioid and simply inhaled (and not associated with respiratory depression), so the patient can be given fast, effective pain relief, minimising further distress.1,2