Penthrox® Europe
Penthrox® Europe

This website is an information resource about Penthrox® intended for healthcare professionals only.

I am a healthcare professional

Patients who have been given Penthrox® can find the Patient Information Leaflet (PIL) here.

Report adverse events

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. By reporting side effects, you can help provide more information on the safety of medicine.

Mundipharma routinely monitors the safety of all its medicines, including reviewing safety data from clinical studies and collecting reports of adverse events. If you are a patient or are aware of a patient who has experienced an adverse event, overdose or unexpected benefits with one of our products, please also contact Mundipharma by calling +44 (0) 1223 424 211 or by emailing Mundipharma will only use your details to contact you about your adverse event report.

Penthrox® is a registered trademark of Medical Developments International Limited and is used under licence. The Mundipharma network of independent associated companies has exclusive rights in 40 European countries, but excluding the UK and Ireland.

Copyright © 2020 Mundipharma International Limited. All rights reserved.


Your first response to trauma pain

Penthrox® offers effective pain relief within
6-10 breaths 1,2

Patient-controlled pain relief

Penthrox® is a compact, lightweight, hand-held inhaler containing an analgesic dose of methoxyflurane. It is self-administered under supervision of a person trained in its administration and licensed for emergency relief of moderate-to-severe pain in conscious adult patients with trauma and associated pain.1

Please always refer to your local Summary of Product Characteristics.

Penthrox® has been used for over 40 years in Australia and New Zealand, with a total of over 6 million administrations.2,3,53

Clinical experience

over 40 yrs

Take a closer look

Press play to find out more about the innovative yet simple design of the Penthrox® inhaler.

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How could Penthrox® help you?

Non-opioid analgesic can be administered under the supervision of healthcare professionals such as nurses and paramedics.1,2

Penthrox® is easy to administer and can help overcome delays with analgesia administration vs. IV opioids.1,4

Because Penthrox® is easily portable and self-administered, multiple patients can be treated simultaneously.1,5

Rapid analgesic administration may improve patient flow.6

Effective pain relief

The recommended dose of Penthrox® is one 3mL bottle, used with the inhaler.1 A second bottle can be given if required, but most patients (8/10) require only one dose for effective pain relief.2


Easy dosing1

One dose = 1 x 3mL bottle, vaporised in a Penthrox® inhaler.

Maximum dose = 6mL daily.

No more than 15mL per week (non-consecutive days).

Sustained pain relief1,10

One 3mL Penthrox® bottle delivers:

Continuous use = 25–30mins.1

Intermittent use = Up to 59mins.2

Using Penthrox® is as simple as 1, 2, 31

Penthrox® is not an opioid, it can be nurse or emergency crew initiated. The three easy steps to remember are: Pour, Breathe, Regulate, as shown in the guide.


Having ensured the activated carbon (AC) chamber is inserted into the dilutor hole on the top of the inhaler; rotate and tilt the inhaler then pour the entire contents of one 3mL bottle of Penthrox® into the base.


Ask patients to inhale through the mouthpiece, taking gentle breaths at first, then normal breaths, exhaling into the inhaler. For stronger analgesia, the patient can cover the dilutor hole on the AC chamber with a finger.


Instruct patients to inhale intermittently. Continuous inhalation shortens usage time. Use the minimum dose (3mL) to achieve analgesia. When finished, reseal the bottle and dispose of it with the inhaler, responsibly, in a sealed plastic bag.

Watch Penthrox® in action

Press play to see how to use Penthrox®

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Penthrox® – proven first response pain relief in pre-hospital settings and in the emergency department1

Penthrox® offers simple, fast, effective trauma pain relief for patients that can be used by first responders outside or inside the hospital.1 Choose your setting to see a few examples.

Compact, portable, non-opioid Penthrox® can provide fast pain relief in many emergency situations,1 please click on a picture to read the case study.

Superficial injuries
Sprains / strains

Penthrox® is not an opioid,1 it can provide useful, ‘bridging’ analgesia, and help overcome delays with analgesia administration vs. IV opioids.8

  • Simple – Penthrox® is compact, lightweight and portable, it’s easy to use and enables patients to control their own pain.1
  • Fast – Penthrox® can be given quickly and works fast.1,2 Rapid administration of effective analgesia not only relieves unnecessary patient suffering, it may also improve patient flow through the emergency room.6,9,10
  • Effective – Penthrox® significantly reduces pain severity (vs. standard of care; p<0.001 for overall treatment effect, all time points up to 20 minutes; adult population >18 years)55

What our experts say

Penthrox® has been used for over 40 years in Australia and New Zealand,3 take a look at the video to hear about Nurse Agnès Verdetti’s experience.

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What our experts say

An interview with Professor Paul Middleton talking about the place of Penthrox® in emergency medicine.

Play video